Why the study?
Does nitrendipine or enalapril improve renal hemodynamics and morphology in rats with renovascular hypertension?
Population
Rats with two-kidney, one clip renovascular hypertension (n=26) and sham-operated normotensive controls (n=8)
Comparison
Nitrendipine or enalapril for 6 weeks vs Untreated hypertensive controls and…
Design
Preclinical, randomly assigned
Follow-up
6 weeks
Authors
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Nitrendipine may worsen renal injury in renovascular hypertension models; leaves open differential renal effects of CCBs versus ACEIs in humans.
Does nitrendipine or enalapril improve renal hemodynamics and morphology in rats with renovascular hypertension?
In a rat model of renovascular hypertension, the calcium channel blocker nitrendipine worsened albuminuria and glomerulosclerosis, unlike the ACE inhibitor enalapril.
Wenzel et al. (1992) studied this question.
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