Why the study?
Does combined therapy with nitrendipine and enalapril improve blood pressure and renal outcomes in rats with renovascular hypertension?
Population
Rats with two-kidney, one clip renovascular hypertension
Comparison
Combined therapy with nitrendipine and enalapril vs Enalapril alone, enalapril combined with…
Design
Preclinical
Authors
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Preclinical support for testing combination therapy; leaves open translation to human renovascular hypertension.
Does combined therapy with nitrendipine and enalapril improve blood pressure and renal outcomes in rats with renovascular hypertension?
In a rat model of renovascular hypertension, combining nitrendipine with enalapril normalizes blood pressure and prevents the adverse renal structural and functional effects seen with nitrendipine monotherapy.
Wenzel et al. (1994) studied this question.