Why the study?
Does nifedipine have differential regional vascular effects in spontaneously hypertensive rats compared to normotensive rats?
Population
Male 18-week-old normotensive Wistar Kyoto rats and spontaneously hypertensive rats anesthetized with…
Comparison
Nifedipine vs Comparison between SHR and WKY strains
Design
Preclinical
Authors
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Nifedipine shows strain-specific regional vascular effects in hypertensive rats; hypothesis-generating and should not yet influence clinical hypertension management.
Does nifedipine have differential regional vascular effects in spontaneously hypertensive rats compared to normotensive rats?
Nifedipine demonstrates strain-specific regional vascular effects, with greater reduction in renal vascular resistance in hypertensive rats compared to normotensive controls.
Reed et al. (1986) studied this question.
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