October 1, 1987Cardiovascular Research

Improved myocardial capillarisation in spontaneously hypertensive rats treated with nifedipine

View Full Paper

Ask AI

Bookmark

Why the study?

Does nifedipine improve myocardial capillarity in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats

Comparison

Nifedipine mixed into commercial rat chow for 20… vs Untreated spontaneously hypertensive rats and…

Design

Preclinical

Follow-up

20 weeks

Authors

ZTZ. TurekUniversity Hospital Hradec Králové KKK KubátUniversity of Pardubice SKS. KazdaUniversity of Ottawa

Discussion

Member takes

Implication

Nifedipine normalizes capillary spacing in hypertensive rat hearts; leaves open translation to human hypertension or outcomes.

Structured PICO

Does nifedipine improve myocardial capillarity in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats

Intervention

Nifedipine mixed into commercial rat chow (0.3 g per 1 kg) for 20 weeks

Comparator

Untreated spontaneously hypertensive rats and Wistar-Kyoto rats used as controls

Outcome

Myocardial capillarity (mean intercapillary distance and index of heterogeneity of capillary spacing)surrogate

Nifedipine treatment normalizes myocardial capillary spacing in spontaneously hypertensive rats despite persistent hypertension and cardiomegaly.

Cite This Study

Turek et al. (1987) studied this question.

synapsesocial.com/papers/6a87d35b8a3f93fc1e062549 https://doi.org/10.1093/cvr/21.10.725

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Improved myocardial capillarisation in spontaneously hypertensive rats treated with nifedipine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Improved myocardial capillarisation in spontaneously hypertensive rats treated with nifedipine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider