Why the study?
Does chronic nifedipine treatment alter cardiac inotropic response and Ca2+ channel density in adult male New Zealand White rabbits?
Population
Adult male New Zealand White rabbits (NZW), n=14 (7 control, 7 treated)
Comparison
Nifedipine 20 mg/day for 25 days vs Control group (untreated)
Design
Preclinical
Follow-up
25 days
Authors
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May explain preserved contractility on chronic nifedipine; hypothesis-generating in rabbits, human confirmation required before any clinical inference.
Does chronic nifedipine treatment alter cardiac inotropic response and Ca2+ channel density in adult male New Zealand White rabbits?
Chronic nifedipine treatment upregulates functional calcium channels in cardiac muscle, providing a mechanistic explanation for preserved contractility in hypertensive patients on chronic therapy.
Cingolani et al. (1996) studied this question.