Why the study?
Does nifedipine prevent diastolic abnormalities in isolated rat hearts subjected to low-flow ischemia and pacing tachycardia?
Population
Isolated perfused rat hearts subjected to low-flow ischemia and pacing tachycardia
Comparison
Nifedipine (3 x 10(-8) M) pretreatment vs Untreated hearts under the same conditions
Design
Preclinical
Authors
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Should not change clinical practice in ischemia; hypothesis-generating for calcium blockade in diastolic dysfunction.
Does nifedipine prevent diastolic abnormalities in isolated rat hearts subjected to low-flow ischemia and pacing tachycardia?
Nifedipine prevents pacing-induced diastolic abnormalities in an isolated rat heart model of ischemia, suggesting a role for calcium movement in ischemic ventricular stiffness.
Momomura et al. (1991) studied this question.
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