March 1, 1996Clinical and Experimental Pharmacology and Physiology

Relationship Between Nifedipine Sensitivity of Aortae and Blood Pressure of Stroke‐prone Spontaneously Hypertensive Rats

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Why the study?

Does altering blood pressure change the sensitivity of aortic smooth muscle to nifedipine in SHRSP and WKY rats?

Population

Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY)

Comparison

SHRSP treated with antihypertensives to lower… vs Untreated SHRSP and untreated WKY rats

Design

Preclinical

Follow-up

8-10 weeks (from 5 weeks to 13-15 weeks of age)

Authors

GJGuang‐Chi JiangThe Royal Melbourne Hospital VIV. IwanovThe Royal Melbourne Hospital RMRobert F.W. MouldsTherapeutic Guidelines

Discussion

Member takes

Implication

Supports primary vascular calcium alterations in SHRSP independent of BP levels; hypothesis-generating with no immediate clinical implications.

Structured PICO

Does altering blood pressure change the sensitivity of aortic smooth muscle to nifedipine in SHRSP and WKY rats?

Population

Stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY)

Intervention

SHRSP treated with antihypertensives (hydralazine plus hydrochlorothiazide; captopril plus hydrochlorothiazide; hydralazine plus guanethidine; or captopril alone) to lower blood pressure, and WKY treated with deoxycorticosterone acetate (DOCA) and NaCl to raise blood pressure, from 5 weeks to 13-15 weeks of age

Comparator

Untreated SHRSP and untreated WKY rats

Outcome

Sensitivity to inhibition by nifedipine of noradrenaline-induced contractures of aortic rings (measured by area-under-curve analysis)surrogate

Alterations in voltage-dependent calcium mechanisms in stroke-prone spontaneously hypertensive rats appear to be a primary phenomenon independent of blood pressure levels.

Cite This Study

Jiang et al. (1996) studied this question.

synapsesocial.com/papers/6a843f90c2c8a33f31f7a181 https://doi.org/10.1111/j.1440-1681.1996.tb02599.x

Topics

Hypertension management

View Full Paper

Ask AI

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Implication

Supports primary vascular calcium alterations in SHRSP independent of BP levels; hypothesis-generating with no immediate clinical implications.

Relationship Between Nifedipine Sensitivity of Aortae and Blood Pressure of Stroke‐prone Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Relationship Between Nifedipine Sensitivity of Aortae and Blood Pressure of Stroke‐prone Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider