Why the study?
Does nifedipine improve the relaxant effect in aortic smooth muscle from hypertensive rats compared to nitroglycerin?
Population
Aortas of spontaneously hypertensive rats, renal hypertensive rats, and DOCA salt hypertensive rats
Comparison
Nifedipine vs Nitroglycerin
Design
Preclinical
Authors
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Nifedipine enhances aortic relaxation sensitivity in hypertensive rat models unlike nitroglycerin; leaves open human translation and clinical relevance.
Does nifedipine improve the relaxant effect in aortic smooth muscle from hypertensive rats compared to nitroglycerin?
Aortic smooth muscle from hypertensive rats shows increased sensitivity to the relaxant effects of nifedipine, but not nitroglycerin, correlating with the degree of hypertension.
Cattaneo et al. (1986) studied this question.
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