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April 1, 2014The FASEB Journal

Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency (1165.6)

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Why the study?

Does PPADS attenuate the exercise pressor reflex in rats with peripheral artery insufficiency?

Population

Decerebrated, unanesthetized rats whose femoral arteries were either freely perfused or were ligated 72…

Comparison

PPADS, a P2X receptor antagonist, infused into… vs Baseline response before infusing PPADS

Design

Preclinical

Authors

ASAudrey J. StoneKYKatsuya YamauchiMKMarc P. Kaufman

Discussion

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Overview

Should not yet change practice in peripheral artery disease; hypothesis-generating for P2X receptor role in ischemic exercise pressor reflex.

Structured PICO

Does PPADS attenuate the exercise pressor reflex in rats with peripheral artery insufficiency?

P
Population
Decerebrated, unanesthetized rats whose femoral arteries were either freely perfused or were ligated 72 hours before the start of the experiment
I
Intervention
PPADS (10 mg/kg), a P2X receptor antagonist, infused into the arterial supply of the hind limb muscles that were statically contracted
C
Comparator
Baseline response before infusing PPADS
O
Outcome
Peak pressor responses to contractionsurrogate

P2X receptors mediate the exercise pressor reflex in rats with peripheral artery insufficiency, but not in those with normal perfusion.

Cite This Study

Stone et al. (2014) studied this question.

synapsesocial.com/papers/6a833769a250d11ff44cdfbdhttps://doi.org/10.1096/fasebj.28.1_supplement.1165.6
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