Key result
Popliteal arterial injection of the P2 receptor antagonist PPADS attenuated the pressor response to static muscle contraction from 36 mmHg to 14 mmHg (P<0.001) in decerebrate cats.
Why the study?
Does blockade of P2 receptors within contracting skeletal muscle attenuate the exercise pressor reflex in decerebrate cats?
Does blockade of P2 receptors within contracting skeletal muscle attenuate the exercise pressor reflex in decerebrate cats?
Absolute Event Rate: 14% vs 36%
p-value: p=<0.001
P2 receptors on the endings of thin fiber muscle afferents play a role in evoking both the metabolic and mechanoreceptor components of the exercise pressor reflex.
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Hypothesis-generating for P2 receptor role in muscle afferents; leaves open translation to human exercise pressor reflex.
Hanna et al. (2003) studied Exercise pressor reflex (n=19). PPADS (P2 receptor antagonist) vs. Baseline (before injection) was evaluated on Pressor response to static contraction of the triceps surae muscles (p=<0.001). Popliteal arterial injection of the P2 receptor antagonist PPADS attenuated the pressor response to static muscle contraction from 36 mmHg to 14 mmHg (P<0.001) in decerebrate cats.
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