In this small cohort, fibromuscular dysplasia was not associated with endothelial dysfunction, impaired arterial compliance, increased carotid artery IMT, or decreased ABIs.
Endothelial function appears preserved in FMD; hypothesis-generating and requires confirmation in larger prospective cohorts.
There have been no studies to date on the pathophysiologic mechanisms of how fibromuscular dysplasia (FMD) affects vascular function. Due to the perturbations in the blood vessel wall and the propensity for stenosis, dissection, and aneurysms seen in arteries with FMD, subjects with FMD may have impairment in endothelial function and abnormalities in arterial compliance.
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Nicole Wake Jeffrey W Olin (2015) studied this question.
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