January 1, 1984Japanese Heart JournalOpen Access

Rabbit hearts for the critical evaluation of drugs to reduce the size of experimentally produced acute myocardial infarction.

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Why the study?

Do beta blockers and calcium channel blockers reduce acute myocardial infarction size in a rabbit model?

Population

More than 500 male albino rabbits weighing 1.6 to 2.1 Kg subjected to experimental acute myocardial…

Comparison

Propranolol, verapamil, diltiazem, dilazep, or… vs Physiological saline administered intravenously.

Design

Preclinical

Follow-up

24 hours

Authors

TTTeruhiko Toyo‐okaKitasato University Hospital TKToshiro KamishiroNippon Chemiphar (Japan)HFHiroyuki FuminoUniversity of Tsukuba

Discussion

Member takes

Implication

Provides hypothesis-generating data on propranolol and verapamil in rabbit AMI; does not support clinical adoption without further study.

Structured PICO

Do beta blockers and calcium channel blockers reduce acute myocardial infarction size in a rabbit model?

Population

More than 500 male albino rabbits weighing 1.6 to 2.1 Kg subjected to experimental acute myocardial infarction via coronary artery ligation.

Intervention

Propranolol (1, 2, 4 mg/Kg), verapamil (0.25, 0.5, 1.0 mg/Kg), diltiazem (2 mg/Kg), dilazep (2 mg/Kg), or nicardipine (0.01, 0.05, 0.1 mg/Kg) administered intravenously (half dose 5 min before ligation, 1/4 infused for 1 hour after, 1/8 at 2 and 3 hours after).

Comparator

Physiological saline administered intravenously.

Outcome

Acute myocardial infarction (AMI) size, expressed as the percentage of the left ventricular size, determined by phosphorylase histochemistry 24 hours after operation.surrogate

This rabbit model demonstrates that propranolol, verapamil, diltiazem, and dilazep effectively reduce acute myocardial infarction size, while nicardipine does not.

Cite This Study

Toyo‐oka et al. (1984) studied this question.

synapsesocial.com/papers/6a83379e3209de24b7d4f39f https://doi.org/10.1536/ihj.25.623

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Rabbit hearts for the critical evaluation of drugs to reduce the size of experimentally produced acute myocardial infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rabbit hearts for the critical evaluation of drugs to reduce the size of experimentally produced acute myocardial infarction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider