Regenerative technologies in treatment of diabetic foot ulcers

Regenerative medicine is one of the new fast growing approaches to the treatment of a variety of diseases, including oncology and cardiovascular pathology, degenerative-dystrophic diseases of bones and joints, and other complex diseases including diabetes mellitus. Diabetes is regarded as one of the most dangerous non-infectious diseases in the world with a rising incidence that reaches pandemic proportions. Treatment of patients with diabetic foot ulcers including those with peripheral arterial disease is a challenging issue due to the increased risks for poor and lethal outcomes, which makes the social and economic burden of diabetes mellitus very high. The article presents state-of-the-art regenerative technologies in treatment of diabetic foot ulcers. Special attention is paid to gene and cell therapy.