Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans
Why the study?
Does vitamin C restore endothelium-dependent vasodilation impaired by acute hyperglycemia in healthy humans?
Population
Healthy nondiabetic humans
Comparison
Vitamin C coadministered during 6 hours of… vs Hyperglycemia without vitamin C, euglycemia, and…
Design
Other
Follow-up
6 hours
Authors
Discussion
Loading...
Member takes
Implication
Suggests oxidant stress mediates acute hyperglycemia-induced endothelial impairment; leaves open clinical benefit of vitamin C in patients.
Structured PICO
Does vitamin C restore endothelium-dependent vasodilation impaired by acute hyperglycemia in healthy humans?
P
Population
Healthy nondiabetic humans
I
Intervention
Vitamin C (24 mg/min) coadministered during 6 hours of hyperglycemia (300 mg/dL) created by dextrose (50%) intra-arterial infusion
C
Comparator
Hyperglycemia without vitamin C, euglycemia, and equimolar infusions of mannitol with and without vitamin C
O
Outcome
Endothelium-dependent vasodilation measured by incremental brachial artery administration of methacholine chloride (0.3 to 10 microg/min)surrogate
Vitamin C administration restores endothelium-dependent vasodilation impaired by acute hyperglycemia in healthy humans, suggesting hyperglycemia impairs vascular function via oxidant stress.
Cite This Study
Beckman et al. (2001) studied this question.