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September 1, 2026Journal of the American College of Cardiology

Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery

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Key result

Induced hyperglycemia links to rapid suppression of flow-mediated vasodilation in IGT and DM.

  • P<0.01
  • n=58

Why the study?

Chronic hyperglycemia causes endothelial dysfunction in diabetes, but many patients with type 2 diabetes or impaired glucose tolerance experience hyperglycemia only postprandially, prompting study into whether acute hyperglycemia induces endothelial dysfunction.

Population

58 subjects (17 with NGT, 24 with IGT, and 17 with type 2 DM)

Comparison

Oral glucose loading across NGT, IGT, and type 2 DM groups

Follow-up

2-h

Authors

HKHiroaki KawanoKumamoto Health Science UniversityTMTakeshi MotoyamaOkayama University of ScienceOHOsamu HirashimaFukuoka Tokushukai Hospital

Discussion

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Implication

Physiological study reveals acute hyperglycemia rapidly impairs flow-mediated vasodilation in the brachial artery, indicating immediate vascular harm from elevated blood glucose.

Key Points

  • To determine whether acute elevation of blood glucose concentrations rapidly impairs flow-mediated, endothelium-dependent vasodilation in the human brachial artery.
  • Measured flow-mediated, endothelium-dependent vasodilation of the brachial artery before and after acute induction of hyperglycemia.
  • Assessed changes in arterial diameter and vascular reactivity in response to reactive hyperemia.
  • Acute hyperglycemia rapidly and significantly suppresses flow-mediated endothelium-dependent dilation in the brachial artery.
  • High blood glucose levels directly and immediately trigger transient endothelial dysfunction in peripheral conduit arteries.

Study Design

Type

Observational (n=58)

PICO

P
Population
58 subjects (17 with normal glucose tolerance, 24 with impaired glucose tolerance, and 17 with type 2 diabetes mellitus) undergoing an oral glucose tolerance test.
E
Exposure / Comparator
Oral glucose loading vs Fasting state
O
Primary Outcome
Flow-mediated endothelium-dependent vasodilation, p=< 0.01

Main Result

p-value: p=< 0.01

Cite This Study

Kawano et al. (1999) conducted an observational in Type 2 diabetes mellitus and impaired glucose tolerance (n=58). Oral glucose loading vs. Fasting state was evaluated on Flow-mediated endothelium-dependent vasodilation (p=< 0.01). Hyperglycemia induced by oral glucose loading rapidly suppressed flow-mediated endothelium-dependent vasodilation, with significant decreases at 1 hour in IGT and DM groups (P<0.01 vs fasting).

synapsesocial.com/papers/6a97413a46f92c834ccf7acehttps://doi.org/10.1016/s0735-1097(99)00168-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulatory Functions of the Vascular Endothelium1990 · 1,902 citations
  2. 2Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.1996 · 876 citations
  3. 3Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo1995 · 1,627 citations
  4. 4The Peripheral Circulation: Local Regulation1978 · 62 citations
  5. 5Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications1988 · 2,526 citations