Prasugrel Versus Clopidogrel Antiplatelet Therapy for Flow Diverter Treatment for Cerebral Aneurysms: A Retrospective Study

Masanori Sato; Yosuke Nishimuta; Daichi Fukuzoe; Nao ONOBUCHI; Masayuki Yamagishi; Hiroshi Hosoyama; Tadaaki Niiro; Ayumi Taniguchi; Hiroshi Tokimura; Fumio Miyashita; Ryosuke Hanaya

doi:10.2335/scs.52.453

January 1, 2024Surgery for Cerebral StrokeOpen Access

Prasugrel Versus Clopidogrel Antiplatelet Therapy for Flow Diverter Treatment for Cerebral Aneurysms: A Retrospective Study

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Why the study?

Does prasugrel improve the stability of P2Y12 reaction units within the therapeutic window compared to clopidogrel in patients undergoing flow diverter treatment for cerebral aneurysms?

Structured PICO

Does prasugrel improve the stability of P2Y12 reaction units within the therapeutic window compared to clopidogrel in patients undergoing flow diverter treatment for cerebral aneurysms?

P

Population

43 consecutive patients who underwent flow diverter (FD) treatment for cerebral aneurysms at a single institution in Japan between April 2020 and August 2023. Mean age 62.2 years, 38 females, 5 males.

I

Intervention

Prasugrel 3.75 mg once daily combined with aspirin 100 mg, initiated two weeks prior to flow diverter treatment.

C

Comparator

Clopidogrel 75 mg once daily combined with aspirin 100 mg, initiated two weeks prior to flow diverter treatment.

O

Outcome

Number of patients within the P2Y12 reaction unit (PRU) therapeutic window (60 < PRU < 200) preoperatively, postoperatively, and at the final assessment.surrogate

Limitations

Single-center retrospective study
Small sample size
Only VerifyNow system used for assessment
CYP2C19 genetic polymorphism not evaluated

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Implication

Prasugrel effectively stabilized platelet reactivity within the therapeutic window during the perioperative period of flow diverter treatment for cerebral aneurysms, requiring fewer dose adjustments than clopidogrel.

Abstract

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Discussion

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Cite This Study

Sato et al. (2024) studied this question.

synapsesocial.com/papers/6a8339cd292d2964071f31e2 https://doi.org/10.2335/scs.52.453

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Prasugrel Versus Clopidogrel Antiplatelet Therapy for Flow Diverter Treatment for Cerebral Aneurysms: A Retrospective Study

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Prasugrel Versus Clopidogrel Antiplatelet Therapy for Flow Diverter Treatment for Cerebral Aneurysms: A Retrospective Study

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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