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November 1, 2000Molecular and Cellular Biology

CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1

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Authors

KCKendall D. CareySan Francisco VA Medical CenterTDTara J. DillonUniversity of MinnesotaJSJohn SchmittSaint Joseph Seminary College

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Carey et al. (2000) studied this question.

synapsesocial.com/papers/6a83404065d10cbb45d9cb44https://doi.org/10.1128/mcb.20.22.8409-8419.2000
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Also Consider

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  1. 1Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs1996 · 599 citations
  2. 2The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion2000 · 416 citations
  3. 3Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection.1996 · 74 citations
  4. 4The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP.1993 · 224 citations