Why the study?
Do strophanthin and quinidine affect conduction and the Q-T interval in the isolated rabbit heart?
Do strophanthin and quinidine affect conduction and the Q-T interval in the isolated rabbit heart?
In an isolated rabbit heart model, strophanthin and quinidine delay recovery and prolong refractoriness, with dose-dependent and variable effects on the Q-T interval.
Warrants no change in clinical practice; leaves open translation of rabbit-heart refractoriness and QT effects to humans.
Recovery curves of conductivity of the A-V node and ventricles for the isolated rabbit heart driven at various rates followed the usual logarithmic pattern. Strophanthin, and especially quinidine, caused delayed recovery and more prolonged refractoriness of both regions of the heart. Strophanthin prolonged the Q-T interval in small doses and usually shortened it in larger doses. Quinidine effects upon the Q-T interval were unexpectedly variable, contrary to the usual prolongation in thyrotron driven ventricles and in clinical cases.
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Ruskin et al. (1948) studied this question.
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