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February 1, 1991Journal of Cardiovascular Pharmacology

Effects of Quinidine on Arrhythmias and Conduction in an Isolated Tissue Model of Ischemia and Reperfusion

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Why the study?

Does quinidine suppress reperfusion arrhythmias and alter conduction in an isolated guinea pig tissue model of ischemia and reperfusion?

Population

Isolated segments of guinea pig right ventricles exposed to ischemic conditions for 15 min and then…

Comparison

Quinidine at concentrations of 1, 5, 10, 50, and… vs Control hearts (no quinidine)

Design

Preclinical

Follow-up

15 minutes of ischemia followed by early reperfusion

Authors

GLGui‐Rong LiBinzhou UniversityGFGregory R. FerrierDalhousie University

Discussion

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Implication

May support concentration-dependent antiarrhythmic effects of quinidine in reperfusion; leaves open clinical translation from guinea pig models.

Structured PICO

Does quinidine suppress reperfusion arrhythmias and alter conduction in an isolated guinea pig tissue model of ischemia and reperfusion?

P
Population
Isolated segments of guinea pig right ventricles exposed to ischemic conditions for 15 min and then reperfused with normal Tyrode's solution
I
Intervention
Quinidine at concentrations of 1, 5, 10, 50, and 100 microM
C
Comparator
Control hearts (no quinidine)
O
Outcome
Incidence of reperfusion arrhythmias (ventricular tachycardia, bigeminy, or trigeminy) and changes in transmural conduction time and endocardial effective refractory periodsurrogate

Low concentrations of quinidine may suppress reperfusion arrhythmias through differential effects dependent on tissue anisotropy.

Cite This Study

Li et al. (1991) studied this question.

synapsesocial.com/papers/6a853eb60743ff3319d9803ahttps://doi.org/10.1097/00005344-199102000-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quinidine elicits proarrhythmic changes in ventricular repolarization and refractoriness in guinea-pig2013 · 18 citations
  2. 2Effects of Quinidine on Repolarization in Canine Epicardium, Midmyocardium, and Endocardium1997 · 40 citations
  3. 3Effects of Quinidine on Repolarization in Canine Epicardium, Midmyocardium, and Endocardium1997 · 75 citations
  4. 4Electrophysiologic Effects of Quinidine1966 · 83 citations
  5. 5Cardiac effects of quinidine on guinea‐pig isolated perfused hearts after <i>in vivo</i> quinidine pretreatment1997 · 5 citations