Why the study?
Does quinidine alter the balance among active and passive cellular properties that determine excitability in sheep Purkinje fibers?
Does quinidine alter the balance among active and passive cellular properties that determine excitability in sheep Purkinje fibers?
Quinidine alters passive cellular properties in sheep Purkinje fibers, which can increase or decrease excitability depending on potassium concentration, providing mechanistic insight into its antiarrhythmic and arrhythmogenic potential.
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Quinidine may exert potassium-dependent effects on excitability in animal fibers; leaves open human translation and clinical relevance.
Arnsdorf et al. (1987) studied this question.
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