Key result
Quinidine sulphate 50 muM reduced the maximum rate of depolarization, total amplitude, and plateau of the action potential in frog auricular fibres by altering ionic conductances.
Population
Frog auricular trabeculae
Design
Preclinical
Authors
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May inform quinidine's ionic mechanisms in cardiac tissue; leaves open translation to mammals or clinical use.
Quinidine alters frog auricular action potentials by reducing sodium and calcium conductances and delaying reactivation kinetics.
Pierre Ducouret (1976) studied this question. Quinidine sulphate was evaluated on Membrane electrical activity (transmembrane currents and action potential parameters). Quinidine sulphate 50 muM reduced the maximum rate of depolarization, total amplitude, and plateau of the action potential in frog auricular fibres by altering ionic conductances.
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