Population
Rat ventricular myocytes
Design
Preclinical
Authors
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Confirms open-state Ito block by quinidine in rat ventricle; leaves open translation to human repolarization disorders.
Quinidine blocks outward K+ currents in rat ventricular cells primarily by acting on the open state of these channels, prolonging repolarization.
Clark et al. (1995) studied this question.
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