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July 1, 1991British Journal of PharmacologyOpen Access

Quinidine‐induced inhibition of the fast transient outward K+ current in rat melanotrophs

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Key result

Quinidine caused a dose-dependent reduction of the peak amplitude of the fast transient outward K+ current in rat melanotrophs, with an estimated Kd of 41 µM at 0 mV.

Population

Acutely dissociated melanotrophs from the neuro-intermediate lobe of the pituitary gland of adult male…

Comparison

Quinidine and structural analogues. vs Control recording solution (0 microM quinidine).

Design

Preclinical

Authors

SKSteven J. KehlLawrence Livermore National Laboratory

Discussion

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Implication

Quinidine's K+ channel effects in rat melanotrophs warrant mechanistic follow-up; leaves open any human relevance.

Structured PICO

P
Population
In vitro electrophysiological study of acutely dissociated melanotrophs from adult male Wistar rats.
I
Intervention
Quinidine (bath application, 5 to 500 microM) and structural analogues (hydroquinidine, quinacrine, cinchonine).
C
Comparator
Control recording solution (0 microM quinidine).
O
Outcome
Peak amplitude and rate of decay of the fast-activating, fast-inactivating potassium current (IK(f)).surrogate

Main Result

Effect estimate: Kd 41 µM (95% CI 30.1-52.04)

Quinidine inhibits the fast transient outward K+ current in rat melanotrophs through both tonic and open channel blocking mechanisms.

Limitations

  • The assumption that the inactivation process is not affected at more depolarized potentials or with higher quinidine concentrations may introduce an unknown degree of error in the analysis.
  • The mechanistic basis for the tonic block remains unknown.

Cite This Study

Steven J. Kehl (1991) studied this question. Quinidine vs. Control medium was evaluated on Blockade of the fast transient outward K+ current (IK(f)) at 0 mV (Kd) (Kd 41 µM, 95% CI 30.1-52.04). Quinidine caused a dose-dependent reduction of the peak amplitude of the fast transient outward K+ current in rat melanotrophs, with an estimated Kd of 41 µM at 0 mV.

synapsesocial.com/papers/6a997d699c12de0c30aab431https://doi.org/10.1111/j.1476-5381.1991.tb09867.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quinidine-induced inhibition of transient outward current in cardiac muscle1987 · 160 citations
  2. 2Tedisamil inactivates transient outward K+ current in rat ventricular myocytes1989 · 82 citations
  3. 3Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons1971 · 937 citations
  4. 4Ionic Blockage of Sodium Channels in Nerve1973 · 1,586 citations
  5. 5Cultured melanotrophs of the adult rat pituitary possess a voltage‐activated fast transient outward current.1989 · 12 citations