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November 1, 1989AJP Heart and Circulatory Physiology

Tedisamil inactivates transient outward K+ current in rat ventricular myocytes

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Why the study?

Does tedisamil affect the transient outward K+ current in rat ventricular myocytes?

Population

Single rat ventricular myocytes

Design

Preclinical

Authors

IDIain DukesBiotrend (Portugal)MMMartin MoradElectrophysiology

Discussion

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Implication

Tedisamil suppresses ito and prolongs APD in rat myocytes; hypothesis-generating for antiarrhythmic potential, translation to humans remains untested.

Structured PICO

Does tedisamil affect the transient outward K+ current in rat ventricular myocytes?

P
Population
Single rat ventricular myocytes
I
Intervention
Tedisamil (1-20 microM)
O
Outcome
Effect on transient outward K+ current (ito) and action potential durationsurrogate

Tedisamil acts as a novel antiarrhythmic agent by primarily suppressing the transient outward K+ current in rat ventricular myocytes.

Cite This Study

Dukes et al. (1989) studied this question.

synapsesocial.com/papers/6a73dc63e3ef2a9a940dd74bhttps://doi.org/10.1152/ajpheart.1989.257.5.h1746
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker1991 · 61 citations
  2. 2Mechanism of block by tedisamil of transient outward current in human ventricular subepicardial myocytes1998 · 45 citations
  3. 3Tedisamil: master switch of nature?2001 · 10 citations
  4. 4Effects of tedisamil (KC‐8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart1996 · 25 citations
  5. 5Frequency-dependent Cardiac Electrophysiologic Effects of Tedisamil: Comparison With Quinidine and Sotalol1997 · 16 citations