Key result
Tedisamil (3 microM) significantly reduced the incidence of ventricular fibrillation in rabbit isolated hearts subjected to hypoxia and reoxygenation compared to control (0% vs 83.3%, P=0.007).
Population
Rabbit isolated hearts
Comparison
Tedisamil 1, 3, and 10 microM perfusion, or 10… vs Control during hypoxia and reoxygenation
Design
Preclinical
Authors
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Tedisamil's effects in isolated hearts require in vivo confirmation; leaves open translation to clinical antiarrhythmic use.
Absolute Event Rate: 0% vs 83.3%
p-value: p=0.007
Tedisamil demonstrates direct antifibrillatory actions in rabbit isolated hearts, likely via modulation of cardiac ATP-regulated potassium channels and antagonism of IK and Ito.
Chi et al. (1996) studied Ventricular fibrillation (n=18). Tedisamil vs. Control was evaluated on Incidence of ventricular fibrillation (p=0.007). Tedisamil (3 microM) significantly reduced the incidence of ventricular fibrillation in rabbit isolated hearts subjected to hypoxia and reoxygenation compared to control (0% vs 83.3%, P=0.007).