Why the study?
Does oral tedisamil prevent lethal ischemic arrhythmias in a postinfarcted canine model of ischemic ventricular fibrillation?
Population
Male mongrel dogs with surgical anterior myocardial infarction who were inducible for ventricular…
Comparison
Oral tedisamil 3 mg/kg, twice daily for 4 days. vs Oral placebo (empty gelatin capsules).
Design
Preclinical, Randomized
Follow-up
4 days
Authors
Loading...
No change to post-MI care; leaves open translation of tedisamil's antiarrhythmic effects to clinical trials.
Does oral tedisamil prevent lethal ischemic arrhythmias in a postinfarcted canine model of ischemic ventricular fibrillation?
In a postinfarcted canine model, oral tedisamil significantly reduced the inducibility of ventricular tachycardia and improved survival during acute ischemia.
Friedrichs et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: