Why the study?
Does tedisamil reduce the initiation and maintenance of ventricular fibrillation in isolated rat hearts during ischemia and reperfusion?
Population
Isolated rat hearts (n = 12/group) subjected to regional ischemia and reperfusion
Comparison
Tedisamil at concentrations of 0.1, 0.55, and 3… vs Control (absence of drug)
Design
Preclinical
Follow-up
30 min of ischemia
Authors
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Supports antiarrhythmic research on tedisamil in ischemic VF; leaves open clinical translation from rat models.
Does tedisamil reduce the initiation and maintenance of ventricular fibrillation in isolated rat hearts during ischemia and reperfusion?
In an isolated rat heart model, tedisamil inhibited the maintenance of ventricular fibrillation during ischemia and reperfusion in a concentration-dependent manner, without affecting its initiation.
Tsuchihashi et al. (1991) studied this question.
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