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December 1, 1997Journal of Cardiovascular Pharmacology and Therapeutics

Frequency-dependent Cardiac Electrophysiologic Effects of Tedisamil: Comparison With Quinidine and Sotalol

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Why the study?

Does tedisamil have different cellular electrophysiologic effects compared to quinidine and sotalol in isolated cardiac preparations?

Population

Isolated dog cardiac Purkinje and ventricular muscle fibers and rabbit left atrial muscle

Comparison

Tedisamil (1 µM) vs Quinidine (10 µM) and sotalol (30 µM)

Design

Preclinical

Authors

MNMiklós NémethUniversity of SzegedAVAndrás VarróElectrophysiologyLVLászló VirágUniversity of Szeged

Discussion

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Implication

Tedisamil's profile may guide antiarrhythmic candidate selection in models; leaves open translation to human preparations or clinical use.

Structured PICO

Does tedisamil have different cellular electrophysiologic effects compared to quinidine and sotalol in isolated cardiac preparations?

P
Population
Isolated dog cardiac Purkinje and ventricular muscle fibers and rabbit left atrial muscle
I
Intervention
Tedisamil (1 µM)
C
Comparator
Quinidine (10 µM) and sotalol (30 µM)
O
Outcome
Cellular electrophysiologic effects including action potential duration, phase 1 repolarization, and maximal rate of depolarization (V(max))surrogate

Tedisamil exhibits unique frequency-dependent cellular electrophysiologic effects, including repolarization lengthening and I(K(ATP)) blockade, resembling chronic amiodarone treatment.

Cite This Study

Németh et al. (1997) studied this question.

synapsesocial.com/papers/6a71639ff44fa9f079df2fd2https://doi.org/10.1177/107424849700200405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antiarrhythmic properties of tedisamil (KC8857), a putative transient outward K+ current blocker1991 · 61 citations
  2. 2Quinidine delays IK activation in guinea pig ventricular myocytes.1988 · 105 citations
  3. 3A third class of anti‐arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 34741970 · 383 citations
  4. 4Comparison of potassium currents in rabbit atrial and ventricular cells.1988 · 385 citations
  5. 5Calcium‐sensitive and insensitive transient outward current in rabbit ventricular myocytes.1989 · 176 citations