Effects of tedisamil, atenolol and their combination on heart andrate‐dependent QT interval in healthy volunteers
Why the study?
Does the combination of tedisamil and atenolol cause excessive bradycardia or QT interval prolongation in healthy male volunteers?
Population
Healthy male volunteers
Comparison
Tedisamil and atenolol alone and in combination vs Each treatment compared against the others in a…
Design
Other
Authors
Discussion
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Member takes
Implication
No excessive bradycardia or QT effects seen with combination in volunteers; leaves open safety in patients.
Structured PICO
Does the combination of tedisamil and atenolol cause excessive bradycardia or QT interval prolongation in healthy male volunteers?
P
Population
Healthy male volunteers
I
Intervention
Tedisamil (100 mg twice daily) and atenolol (50 mg twice daily) alone and in combination
C
Comparator
Each treatment compared against the others in a three-period crossover design
O
Outcome
Heart rate and QT interval duration at rest and during exercise testssurrogate
The combination of tedisamil and atenolol does not cause excessive bradycardia or QT prolongation in healthy volunteers, suggesting a favorable safety profile for coadministration.
Cite This Study
Démolis et al. (1997) studied this question.