Comparison of the potassium channel blocker tedisamil with the beta‐adrenoceptor blocker esmolol and the calcium antagonist gallopamil in patients with coronary artery disease

22 patients with angiographically proven coronary artery disease (CAD) and reproducible ST-segment depression in the exercise electrocardiogram.

Tedisamil 0.3 mg/kg intravenously (i.v.)

Esmolol (i.v. bolus of 500 micrograms/kg, maintenance dose 200 micrograms/kg/min) and gallopamil (initial dose 0.025 mg/kg, maintenance dose 0.0005 mg/kg/h)

Hemodynamic and neurohumoral effects (including heart rate, cardiac output, stroke volume, mean capillary wedge pressure, rate-pressure product, myocardial oxygen consumption, ST-segment depression, plasma lactate, and norepinephrine) at rest and during exercisesurrogate