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February 1, 1988British Journal of PharmacologyOpen Access

Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea‐pig papillary muscle

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Authors

LHLuc M. HondeghemFlanders Marine InstituteTMTetsu MatsubaraAsahikawa Medical College Hospital

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Implication

Informs quinidine's sodium channel kinetics in vitro; leaves open relevance to clinical antiarrhythmic use.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Hondeghem et al. (1988) studied this question.

synapsesocial.com/papers/6a82bda6d7a462ab0d8ae016https://doi.org/10.1111/j.1476-5381.1988.tb11436.x
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Also Consider

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  1. 1Measurement of Vmax of the cardiac action potential with a sample/hold peak detector1978 · 10 citations
  2. 2Mechanisms of quinidine-induced depression of maximum upstroke velocity in ovine cardiac Purkinje fibers.1982 · 47 citations
  3. 3Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction.1980 · 142 citations
  4. 4Lidocaine block of cardiac sodium channels.1983 · 662 citations
  5. 5Maximal upstroke velocity as an index of available sodium conductance. Comparison of maximal upstroke velocity and voltage clamp measurements of sodium current in rabbit Purkinje fibers.1984 · 152 citations