Quinidine delays IK activation in guinea pig ventricular myocytes.
Why the study?
Does quinidine alter the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes?
Population
Acutely disaggregated guinea pig ventricular myocytes (n=8)
Comparison
Quinidine 10 microM vs Baseline (paired) or non-pretreated cells
Design
Preclinical
Authors
Discussion
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Implication
Quinidine's IK effects in guinea pig myocytes are hypothesis-generating; leaves open relevance to human antiarrhythmic therapy.
Structured PICO
Does quinidine alter the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes?
P
Population
Acutely disaggregated guinea pig ventricular myocytes (n=8)
I
Intervention
Quinidine 10 microM
C
Comparator
Baseline (paired) or non-pretreated cells
O
Outcome
Delayed rectifier potassium current (IK) magnitude and activation timesurrogate
Quinidine delays the activation of the delayed rectifier potassium current in guinea pig ventricular myocytes, suggesting it promotes occupancy of a closed channel state.
Cite This Study
Roden et al. (1988) studied this question.