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August 1, 1991Circulation Research

Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone.

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Population

guinea pig ventricular myocytes

Design

Preclinical

Authors

JBJeffrey R. BalserVanderbilt UniversityPBPaul B. BennettPiri Reis UniversityLHLuc M. HondeghemFlanders Marine Institute

Discussion

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Overview

Voltage-dependent IK block differences warrant targeted mechanistic studies; leaves open relevance to human antiarrhythmic efficacy.

Structured PICO

P
Population
guinea pig ventricular myocytes
I
Intervention
quinidine and amiodarone
O
Outcome
suppression of time-dependent outward currentsurrogate

Quinidine and amiodarone suppress time-dependent outward currents in ventricular myocytes through distinct mechanisms, with quinidine exhibiting greater voltage dependence.

Cite This Study

Balser et al. (1991) studied this question.

synapsesocial.com/papers/6a7163a0f44fa9f079df2fd9https://doi.org/10.1161/01.res.69.2.519
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Amiodarone and its Metabolite, Desethylamiodarone, on the Electrophysiologic Properties of Isolated Cardiac Muscle1986 · 96 citations
  2. 2Ionic Blockage of Sodium Channels in Nerve1973 · 1,586 citations
  3. 3Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons1971 · 937 citations
  4. 4Time-dependent outward current in guinea pig ventricular myocytes. Gating kinetics of the delayed rectifier.1990 · 107 citations
  5. 5Ionic basis of the different action potential configurations of single guinea‐pig atrial and ventricular myocytes.1985 · 228 citations