Gating charge and ionic currents associated with quinidine block of human Kv1.5 delayed rectifier channels.
Population
human Kv1.5 (hKv1.5) delayed rectifier channels expressed in human embryonic kidney cells
Comparison
Quinidine (10 to 100 microM) vs Control (no quinidine)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports Kv1.5-targeted drug design; leaves open clinical translation from animal models to human arrhythmias.
Structured PICO
P
Population
human Kv1.5 (hKv1.5) delayed rectifier channels expressed in human embryonic kidney cells
I
Intervention
Quinidine (10 to 100 microM)
C
Comparator
Control (no quinidine)
O
Outcome
Mechanism of quinidine-induced ionic and gating current inhibition (voltage-dependent block and gating charge immobilization)surrogate
Quinidine blocks human Kv1.5 channels by binding to a site that becomes accessible only upon channel opening, without affecting kinetic states prior to opening.
Cite This Study
David Fedida (1997) studied this question.