Population
Mammalian cells expressing human cardiac hKv1.5 channel
Comparison
Site-directed mutagenesis of residues in the… vs Wild-type hKv1.5 channel
Design
Preclinical
Authors
Loading...
No immediate change to quinidine use; leaves open whether S6 variants alter clinical antiarrhythmic response.
Site-directed mutagenesis localizes the hydrophobic binding site for quinidine to the internal mouth of the human hKv1.5 K+ channel, supporting the open channel-block model.
Yeola et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: