Population
Individual Na+ channels from isolated guinea-pig ventricular heart cells
Design
Preclinical
Authors
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No immediate clinical implications for Na+ channel targeting; leaves open translation of pore structure findings to human therapeutics.
The selectivity region of cardiac Na+ channels is narrow and located near the external side, with QX-314 blockade occurring deep within the pore.
Gingrich et al. (1993) studied this question.
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