Bis-quaternary ammonium blockers as structural probes of the sarcoplasmic reticulum K+ channel.

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Structured PICO

Population

Sarcoplasmic reticulum K+ channels inserted into planar phospholipid membranes

Intervention

n-alkyl-bis-alpha,omega-trimethylammonium (bisQn) compounds of varying methylene chain lengths

Outcome

K+ current block and effective valencesurrogate

Bis-quaternary ammonium blockers reveal that 65% of the voltage drop within the sarcoplasmic reticulum K+ channel occurs over a distance of 6-7A.

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Maps SR K+ channel voltage profile in animals; leaves open relevance to human cardiac electrophysiology.

Christopher Miller (1982) studied this question.

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