Key result
Quinidine blocked the open cloned Ito-type cardiac K+ channel (RHK1) in a concentration- and voltage-dependent manner, with an IC50 of 1.69 mM at 0 mV.
Why the study?
Does quinidine block cloned Ito-type cardiac K+ channels in Xenopus oocytes?
Does quinidine block cloned Ito-type cardiac K+ channels in Xenopus oocytes?
Quinidine blocks cloned Ito-type cardiac K+ channels by acting as an open-channel blocker, likely from an intracellular site.
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Characterizes quinidine's Ito block in oocytes; extends prior K+ channel observations but leaves open translation to native tissue and clinical use.
Yatani et al. (1993) studied Cardiac K+ channel currents. Quinidine vs. Control was evaluated on Whole-cell RHK1 current amplitude and single-channel open time. Quinidine blocked the open cloned Ito-type cardiac K+ channel (RHK1) in a concentration- and voltage-dependent manner, with an IC50 of 1.69 mM at 0 mV.
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