Key result
Myocardial disease and ischemia alter cardiac ion channel function potentially at the molecular level.
Why the study?
Myocardial disease and ischemia may alter the electrophysiologic function of cardiac ion channels, but the mechanisms and effects require examination.
Design
Review article
Authors
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May explain ischemia-related arrhythmias; leaves open targeted channel therapies in humans.
This review highlights the mechanistic links between myocardial ischemia, hypertrophy, and altered cardiac ion channel function at the cellular and molecular levels.
Eick et al. (1992) conducted a review in Myocardial disease and ischemia. Myocardial disease and ischemia was evaluated. Myocardial disease and ischemia can alter the electrophysiologic function of cardiac ion channels, including A-like channels and inward rectifiers, potentially at the molecular level.