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September 1, 1997British Journal of PharmacologyOpen Access

Cardiac effects of quinidine on guinea‐pig isolated perfused hearts after in vivo quinidine pretreatment

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Why the study?

Does prolonged in vivo treatment with quinidine induce pharmacological tolerance to its cardiac electrical and mechanical effects in guinea-pigs?

Population

Guinea-pigs (n=14)

Comparison

In vivo pretreatment with quinidine sulphate 75… vs In vivo pretreatment with saline for 6 days…

Design

Preclinical

Follow-up

6 days of pretreatment, followed by ex vivo evaluation 24…

Authors

QYQuan YangUniversity of Hong Kong - Shenzhen HospitalRPRoberto PadriniUniversity of PaduaDPDonatella PiovanUniversity of Padua

Discussion

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Member takes

Implication

Supports no quinidine tolerance in guinea-pig model; leaves open translation to chronic human use.

Structured PICO

Does prolonged in vivo treatment with quinidine induce pharmacological tolerance to its cardiac electrical and mechanical effects in guinea-pigs?

P
Population
Guinea-pigs (n=14)
I
Intervention
In vivo pretreatment with quinidine sulphate 75 mg kg-1 intraperitoneally once daily for 6 days, followed by ex vivo heart perfusion with quinidine at varying concentrations (2-20 microns)
C
Comparator
In vivo pretreatment with saline for 6 days, followed by ex vivo heart perfusion with quinidine
O
Outcome
Cardiac electrical and mechanical responses (maximal derivative of intraventricular pressure [dP/dtmax], coronary perfusion pressure [Cp], PR, QRS, and JT intervals)surrogate

Prolonged in vivo treatment with quinidine does not induce pharmacological tolerance to its electrophysiological and contractility effects in a guinea-pig model.

Cite This Study

Yang et al. (1997) studied this question.

synapsesocial.com/papers/6a7d279ca3b6fd5035d5a677https://doi.org/10.1038/sj.bjp.0701318
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quinidine blocks cardiac sodium channels during opening and slow inactivation in guinea‐pig papillary muscle1988 · 38 citations
  2. 2Effects of pinacidil on guinea‐pig isolated perfused heart with particular reference to the proarrhythmic effect1992 · 32 citations
  3. 3Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone.1991 · 169 citations
  4. 4Action Potential Prolongation Exhibits Simple Dose-Dependence for Sotalol, but Reverse1993 · 45 citations
  5. 5Quinidine is a competitive antagonist at alpha 1- and alpha 2-adrenergic receptors.1984 · 39 citations