Population
17 conscious dogs, studied before and after the development of volume overload left ventricular hypertrophy…
Comparison
Quinidine gluconate administered intravenously… vs Baseline measurements before quinidine…
Design
Preclinical
Follow-up
15 minutes after the second dose
Authors
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Quinidine may unmask negative inotropy when sympathetic drive is blunted; leaves open relevance to human HF management.
Quinidine directly depresses left ventricular performance in both normal and hypertrophied canine hearts, an effect that may be masked by compensatory sympathetic activation in the intact state.
Engler et al. (1979) studied this question.
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