Why the study?
Do sotalol and quinidine alter hemodynamic parameters in patients with frequent ventricular premature depolarizations and depressed cardiac function?
Population
Patients with frequent ventricular premature depolarizations and depressed cardiac function.
Comparison
Sotalol and quinidine vs Placebo
Design
RCT, double-blind
Authors
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Sotalol warrants caution without cardiac reserve despite hemodynamic gains; extends comparative antiarrhythmic data in depressed LV function.
Do sotalol and quinidine alter hemodynamic parameters in patients with frequent ventricular premature depolarizations and depressed cardiac function?
Sotalol and quinidine exert distinct hemodynamic effects in patients with frequent VPDs and depressed cardiac function, with sotalol posing a risk of adverse events in patients lacking cardiac reserve.
Mahmarian et al. (1987) studied this question.
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