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October 6, 1977New England Journal of Medicine

Ventricular Premature Beats and Mortality after Myocardial Infarction

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Key result

The presence of complex ventricular premature beats in men with prior myocardial infarction is associated with a three-fold increased risk of sudden coronary death.

Why the study?

Does the presence of complex ventricular premature beats increase the risk of mortality in men with prior myocardial infarction?

Population

1739 men with prior myocardial infarction

Comparison

Presence of complex premature beats during one… vs Absence of complex ventricular premature beats…

Design

Cohort

Follow-up

up to four years (average, 24.4 months)

Authors

WRWilliam RubermanAmerica's Health Insurance PlansEWEve WeinblattKrankenhaus WaldfriedeJGJudith D. GoldbergNYU Langone Health

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Implication

May refine post-MI sudden death risk stratification; leaves open whether suppressing these beats improves outcomes.

Key Points

  • This research aims to evaluate how ventricular premature beats affect mortality in coronary patients following a myocardial infarction.
  • Monitored 1739 men with prior myocardial infarction for ectopic activity over one hour.
  • Followed participants for mortality for up to four years, averaging 24.4 months.
  • Conducted survival analyses considering important prognostic variables.
  • Presence of complex premature beats is associated with three times the risk of sudden coronary death compared to men without complex beats.
  • Risk of death from any cause is double for men with complex ventricular premature beats compared to those without.
  • The increased risk of death persists throughout the follow-up period.

Study Design

Type

Cohort (n=1,739)

Structured PICO

Does the presence of complex ventricular premature beats increase the risk of mortality in men with prior myocardial infarction?

P
Population
1739 men with prior myocardial infarction
I
Intervention
Presence of complex premature beats (R on T, runs of 2 or more, multiform or bigeminal premature beats) during one hour of monitoring
C
Comparator
Absence of complex ventricular premature beats during the monitoring hour
O
Outcome
Sudden coronary deathhard clinical

Main Result

Effect estimate: RR 3.0

Complex ventricular premature beats identified during a one-hour monitoring period independently predict a significantly increased risk of sudden coronary death and all-cause mortality in men with prior myocardial infarction.

Cite This Study

Ruberman et al. (1977) conducted a cohort in Prior myocardial infarction (n=1,739). Complex ventricular premature beats vs. Absence of complex ventricular premature beats was evaluated on Sudden coronary death (RR 3.0). The presence of complex ventricular premature beats in men with prior myocardial infarction is associated with a three-fold increased risk of sudden coronary death.

synapsesocial.com/papers/6a0e9dfd53f874f2b2228f71https://doi.org/10.1056/nejm197710062971404

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic importance of premature beats following myocardial infarction. Experience in the coronary drug project1973 · 31 citations
  2. 2Relationship between Ventricular Premature Contractions on Routine Electrocardiography and Subsequent Sudden Death from Coronary Heart Disease1973 · 79 citations
  3. 3Epidemiology and Prevention of Ventricular Ectopic Rhythms12015 · 19 citations
  4. 4Predisposing Factors in Sudden Cardiac Death in Tecumseh, Michigan1970 · 156 citations
  5. 5The normal electrocardiogram as a predictor of left ventricular function in patients with coronary artery disease.1977 · 24 citations