What does this research mean for the field?

Moricizine is effective in reducing runs of nonsustained ventricular tachycardia but ineffective in preventing the recurrence of sustained ventricular tachycardia, and is generally well tolerated in patients with low left ventricular ejection fractions. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1986Circulation

Efficacy and safety of moricizine in patients with ventricular tachycardia: results of a placebo-controlled prospective long-term clinical trial.

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Why the study?

Does moricizine reduce runs of nonsustained VT and prevent recurrence of sustained VT in patients with ventricular tachycardia?

Population

50 patients with 10 or more runs of nonsustained ventricular tachycardia on a screening 24 hr ambulatory ECG…

Comparison

Moricizine averaging 10 mg/kg/day vs Placebo

Design

Other, single-blind

Authors

CPCraig M. PrattUniversity of California, Davis AWAnn WiermanValley Health System ASA.Allen SealsSt. Vincent's HealthCare

Discussion

Member takes

Implication

Moricizine may suppress nonsustained VT without preventing sustained recurrences; hypothesis-generating and should not change practice.

Structured PICO

Does moricizine reduce runs of nonsustained VT and prevent recurrence of sustained VT in patients with ventricular tachycardia?

Population

50 patients with 10 or more runs of nonsustained ventricular tachycardia (VT) on a screening 24 hr ambulatory ECG recording. 31/50 had coronary artery disease, mean LVEF 36%, and 20 had a history of sustained VT.

Intervention

Moricizine averaging 10 mg/kg/day

Comparator

Placebo

Outcome

Protocol failure (failure to achieve a 75% or greater reduction in runs of VT as judged by ambulatory ECG recording and/or recurrence of sustained VT while on moricizine)composite

Moricizine effectively reduces nonsustained ventricular tachycardia but fails to prevent the recurrence of sustained ventricular tachycardia.

Cite This Study

Pratt et al. (1986) studied this question.

synapsesocial.com/papers/6a1dd52b66b24d664b60337a https://doi.org/10.1161/01.cir.73.4.718

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Efficacy and safety of moricizine in patients with ventricular tachycardia: results of a placebo-controlled prospective long-term clinical trial.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Efficacy and safety of moricizine in patients with ventricular tachycardia: results of a placebo-controlled prospective long-term clinical trial.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider