Why the study?
Does moricizine therapy suppress ventricular arrhythmias and alter ECG parameters in symptomatic cardiac patients?
Population
17 symptomatic cardiac patients with 30 or more ventricular premature complexes per hour
Comparison
Moricizine therapy vs Pretreatment baseline values
Design
Cohort
Follow-up
over a dosing interval during steady-state therapy
Authors
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May support concentration-guided dosing in symptomatic patients; leaves open need for randomized trials before practice change.
Does moricizine therapy suppress ventricular arrhythmias and alter ECG parameters in symptomatic cardiac patients?
Plasma moricizine concentration correlates with dynamic ECG changes and arrhythmia suppression, but older patients exhibit more marked conduction delays, warranting cautious administration.
Giardina et al. (1994) studied this question.
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