Key result
Low temperatures amplify quinidine's use-dependent conduction and recovery time effects in isolated rabbit hearts.
Why the study?
Does temperature modulation affect quinidine-induced arrhythmias in isolated rabbit hearts?
Population
Isolated perfused rabbit hearts
Comparison
Quinidine at different temperatures and pacing… vs Baseline (no quinidine) at different temperatures
Design
Preclinical
Authors
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No immediate clinical implications for quinidine use; leaves open mechanistic studies of temperature-drug interactions in arrhythmia models.
Does temperature modulation affect quinidine-induced arrhythmias in isolated rabbit hearts?
Temperature modulation reveals that quinidine-induced triggered activity is not solely caused by prolongation of recovery time, highlighting temperature as a tool to study drug mechanisms.
Joseph F. Spear (1998) studied this question. Quinidine and low temperature vs. Baseline was evaluated on Electrophysiological effects (arrhythmias, activation, recovery times). Quinidine's use-dependent effects on conduction and reverse use-dependent effects on recovery time were amplified by low temperatures in isolated rabbit hearts.
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