Why the study?
Does quinidine reduce sodium influx and contraction frequency in cultured rat myocardial cells?
Population
Synchronously contracting rat myocardial cells in monolayer cultures
Comparison
Quinidine (10 M to 10 M) and temperature changes vs Control conditions
Design
Preclinical
Authors
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Quinidine lowers Na influx and contraction frequency in rat myocytes; hypothesis-generating for antiarrhythmic mechanisms, not ready for clinical translation.
Does quinidine reduce sodium influx and contraction frequency in cultured rat myocardial cells?
Quinidine reversibly reduces verapamil-sensitive sodium influx and contraction frequency in cultured rat myocardial cells, demonstrating a close link between sodium movement and automaticity.
David McCall (1976) studied this question.
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