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December 1, 1962American Journal of Physiology-Legacy Content

Effect of high K, low K, and quinidine on QRS duration and ventricular action potential

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Why the study?

Does perfusion with high potassium, low potassium, or quinidine alter QRS duration and ventricular action potential in isolated rabbit hearts?

Population

Isolated rabbit hearts

Design

Preclinical

Authors

LGLeonard S. GettesElectrophysiologyBSBorys SurawiczElectrophysiologyJSJ. C. ShiueUniversity of Vermont

Discussion

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Implication

Does not support clinical changes in potassium or quinidine use; leaves open translation of rabbit-heart mechanisms to human arrhythmias.

Structured PICO

Does perfusion with high potassium, low potassium, or quinidine alter QRS duration and ventricular action potential in isolated rabbit hearts?

P
Population
Isolated rabbit hearts
I
Intervention
Perfusion with high potassium, low potassium, and quinidine solutions
O
Outcome
QRS duration and ventricular transmembrane potential (magnitude, resting potential, and upstroke velocity)surrogate

High potassium, low potassium, and quinidine cause QRS widening in isolated rabbit hearts through distinct mechanisms affecting ventricular action potential upstroke velocity and resting potential.

Cite This Study

Gettes et al. (1962) studied this question.

synapsesocial.com/papers/6a720bfc35aa2c282ce30f8ehttps://doi.org/10.1152/ajplegacy.1962.203.6.1135
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