Why the study?
Does controlled high sodium and water intake prevent hyponatremia and alter hormonal profiles in mechanically ventilated patients with severe SAH?
Population
19 mechanically ventilated patients with severe aneurysmal subarachnoid hemorrhage (SAH)
Design
Cohort
Follow-up
12 days for hormonal assessment, 3 months for clinical…
Authors
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May support high-sodium/water infusion to prevent hyponatremia in ventilated SAH; hypothesis-generating for cerebral salt wasting mechanisms.
Does controlled high sodium and water intake prevent hyponatremia and alter hormonal profiles in mechanically ventilated patients with severe SAH?
In severe SAH, hyponatremia can be prevented by controlled sodium intake, revealing a hormonal profile consistent with cerebral salt wasting syndrome driven by hyperreninemic hypoaldosteronism and increased natriuretic peptides.
Audibert et al. (2009) studied this question.
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