A Rare Case of a Cold Allergic Reaction: A Clinical Case Identified on Autopsy Material

An allergic reaction to cold is a special case of an allergic reaction in which low temperature is a provoking factor. Currently, there are two main theories of cold allergy: allergic and pseudoallergic, in the latter of which cryoglobulin plays a key role. It has been established that there are modified and unmodified risk factors for this type of allergy. These include genetic and non-genetic risk factors, as well as medicinal factors. The article describes a case of an acute allergic reaction to the administration of an iodine-containing radiopaque substance, which led to death. In the blood samples taken during life, a reaction to cold was accidentally detected, which manifested itself in the form of hemolysis, which made it possible to establish the presence of a cold allergy in this patient. Thus, the considered clinical case demonstrates the need for a deeper study of the pathogenesis of cold allergy, including the search for the genetic causes of its development, in order to identify the most likely factors of its occurrence.